Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways

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Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways.

We evaluated the vasorelaxation effects of formononetin, an isoflavone/phytoestrogen found abundantly in Astragalus mongholicus Bunge, on rat isolated aorta and the underlying mechanisms involved. Cumulative administration of formononetin, genistein, daidzein and biochanin A relaxed phenylephrine-preconstricted aorta. Formononetin and biochanin A caused a similar magnitude of relaxation whereas...

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Saffron Induced Relaxation in Isolated Rat Aorta via Endothelium Dependent and Independent Mechanisms

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Saffron Induced Relaxation in Isolated Rat Aorta via Endothelium Dependent and Independent Mechanisms

Crocus sativus L. (saffron) is a widely used food additive for its color and taste. The hypotensive effects of saffron have been shown in previous studies. The aim of this study was to evaluate the mechanism of vasodilatory effects induced by saffron on isolated rat aorta.To study the vasodilatory effects of saffron aqueous extract (0.5, 1 and 2 mg/mL), isolated rat thoracic aorta rings were co...

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ژورنال

عنوان ژورنال: The Journal of Nutritional Biochemistry

سال: 2010

ISSN: 0955-2863

DOI: 10.1016/j.jnutbio.2009.03.010